Genetics of germ cell development
نویسندگان
چکیده
منابع مشابه
genetics of testicular germ cell tumors
testicular germ cell tumor (tgct) is the most solid tumor in 20-40 years old man. tgct account for 95% of testicular tumors and represent a unique type of human cancer from several different perspectives. tgct arise by transformation of germ cells. the transformed germ cells exhibit ploripotentially to differentiate into embryonic. extra-embryonic, and somatic tissue types, and are highly sensi...
متن کاملMolecular genetics of testicular germ cell tumors.
Testicular germ cell tumors (TGCT) are the most common malignancy in young men. While most TGCT are potentially curable, approximately 5% of patients with TGCT may develop chemoresistance and die from the disease. This review article summarizes current knowledge in genetics underlying the development, progression and chemoresistance of TGCT. Most post-pubertal TGCT originate from intratubular g...
متن کاملAn investigation of primordial germ cell development in embryo and larvae of Huso huso
In sturgeons, Primordial Germ Cells originate from the vegetal pole of the egg. They migrate toward genital ridges during developmental stages and finally differentiate into gametes (the only cells that transmit genetic information). In this study, the cells were isolated from the place of migration of primordial germ cells in Huso huso’s larvae during two stages before and after absorption of ...
متن کاملGenetics and biology of adult human male germ cell tumors.
Adult human male germ cell tumors (GCTs) provide a unique opportunity to study the generation of a transformed pluripotential cell from a totipotential GC in lineage differentiation and on the path to gametogenesis. The pluripotentiality of the tumor cells manifests as histological differentiation into GC-like undifferentiated (SE), primitive zygotic (EC), embryonal-like somatically differentia...
متن کاملDynamics of male canine germ cell development
Primordial germ cells (PGCs) are precursors of gametes that can generate new individuals throughout life in both males and females. Additionally, PGCs have been shown to differentiate into embryonic germ cells (EGCs) after in vitro culture. Most studies investigating germinative cells have been performed in rodents and humans but not dogs (Canis lupus familiaris). Here, we elucidated the dynami...
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ژورنال
عنوان ژورنال: Nature Reviews Genetics
سال: 2012
ISSN: 1471-0056,1471-0064
DOI: 10.1038/nrg3294